Hepatpprotective

by Arijit Mondal
(Kolkata)

Original Text: Hepatpprotective


Abstract
Ethanol extract of Melothria heterophylla Lour Cogn. (EEMH) was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. Two different doses (200 and 400 mg/kg, b.w.) of EEMH were administered orally in alternate days. The hepatoprotective activity was studied in liver by measuring biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein and total bilirubin. Lipid peroxidation product and different antioxidant enzyme activities were assessed in liver homogenate. EEMH reduced all the biochemical parameters, and lipid peroxidation, as well as it increased the antioxidant enzyme activities. All the results were compared with silymarin. The protective effect of the extract on CCl4 induced damage was confirmed by histopathological examination of the liver. Therefore the result showed that EEMH has significant hepatoprotective activity against CCl4 induced hepatic damage in rats. This effect may due to presence of flavonoids and saponin in the extract.

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Revised Text:

Hepatoprotective Abstract:

Ethanol extract of Melothria heterophylla Lour Cogn. (EEMH) was investigated for its hepatoprotective activity against CCl4-induced hepatic damage in rats. Two different doses (200 and 400 mg/kg, b.w.) of EEMH were administered orally on alternate days. The hepatoprotective activity was studied in the liver by measuring biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein and total bilirubin.

Lipid peroxidation products and different antioxidant enzyme activities were assessed in liver homogenate. EEMH reduced all the biochemical parameters and lipid peroxidation, as well as increasing the antioxidant enzyme activities. All of the results were compared with silymarin. The protective effect of the extract on CCl4 induced damage was confirmed by histopathological examination of the liver. Therefore the results showed that EEMH has significant hepatoprotective activity against CCl4 induced hepatic damage in rats. This effect may be due to the presence of flavonoids and saponin in the extract.

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