mtDNA Study Summary

by Linda
(Malaysia)

Editor:

1. The edited text of the mtDNA Study Summary is below the divider.

2. Please review the text carefully to ensure your intended meaning was not mistakenly changed. In the first sentence there is uncertainty whether you are speaking of two specific individuals or any two individuals.

Original Text:

In human mtDNA sequence, two individuals only differ due to mutation occurred in the hypervariable regions (Maca-Meyer et al., 2001). This mutation involved nucleotide substitution either transitions or transversions, whereby more nucleotide transitions than transversions and also occupied higher number of pyrimidine transitions than purine transitions in the light strands (Tamura and Nei, 1993; Gunn, 2006). It has been reported that the mutations occurred was resulted from the exposures at high levels of mutagenic free oxygen radical that generated during the mitochondrion energy-generating oxidative phosphorylation process (Gunn, 2006).

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Edited Text:

In the human mtDNA sequence, two individuals differ only due to mutation having occurred in the hypervariable regions (Maca-Meyer et al., 2001.) This mutation involved nucleotide substitution (either transitions or transversions) with more nucleotide transitions than transversions and also occupied a higher number of pyrimidine transitions than purine transitions in the light strands (Tamura and Nei, 1993; Gunn, 2006.)

It has been reported that the mutations which occurred resulted from exposure to high levels of mutagenic free oxygen radicals that generated during the mitochondrion energy-generating oxidative phosphorylation process (Gunn, 2006.)