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Complement Components in Asthma
Objective. To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children. Methods. This case-controlled study comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute attack) and 60 age and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count and serum complements (C3 , C4). Results. Serum C3 was significantly higher in asthmatics when compared to controls (140.60 ± 38.80 mg /dl vs 107.70 ± 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30 ± 48.80 mg/dl vs 44.60 ± 39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3 (p = 0.02) but not with serum C4. Conclusions. Serum levels of C3- but not C4 - are elevated in children with stable asthma, with a positive correlation between serum C3 and severity of asthma. (Indian J Pediatr 2010; 77 (7):771-773) E-mail:maf939@hotmail.com Key words: Asthma; Children; Complement ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Revised Text: Objective: To assess the serum levels of complement factors, C3 and C4, in Egyptian asthmatic children. Methods: This case-controlled study, comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute attack), and 60 age and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count, and serum complements (C3 , C4). Results: Serum C3 was significantly higher in asthmatics, when compared to controls (140.60 ± 38.80 mg /dl vs 107.70 ± 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30 ± 48.80 mg/dl vs 44.60 ± 39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3 (p = 0.02) but not with serum C4. Conclusions: Serum levels of C3, but not C4, are elevated in children with stable asthma, with a positive correlation between serum C3 and severity of asthma. (Indian J Pediatr 2010; 77 (7):771-773) E-mail:maf939@hotmail.com Key words: Asthma; Children; Complement Editor: 1. Please review the text carefully to ensure your intended meaning was not mistakenly changed. 2. Before you leave this page, please take a moment to use the "Click here to post comments." link at the bottom of the page to rate the proofreading and leave a comment if you wish. Proofreading and editing pages that receive ratings and comments are moved to the top of the list. |